La Droga

[Trokji]

Allora visto che volete fare muro contro muro continuiamo a pubblicare studi che non leggerà nessuno senza arrivare a nessuna conclusione utile


ScienceDaily (Apr. 17, 2007) — The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies

They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.
THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.
"The beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," said Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.
Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation. Although a medical derivative of THC, known as Marinol, has been approved for use as an appetite stimulant for cancer patients, and a small number of U.S. states allow use of medical marijuana to treat the same side effect, few studies have shown that THC might have anti-tumor activity, Preet says. The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study in human glioblastoma.
In the present study, the researchers first demonstrated that two different lung cancer cell lines as well as patient lung tumor samples express CB1 and CB2, and that non-toxic doses of THC inhibited growth and spread in the cell lines. "When the cells are pretreated with THC, they have less EGFR stimulated invasion as measured by various in-vitro assays," Preet said.
Then, for three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression, Preet says.
Although the researchers do not know why THC inhibits tumor growth, they say the substance could be activating molecules that arrest the cell cycle. They speculate that THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.
Preet says much work is needed to clarify the pathway by which THC functions, and cautions that some animal studies have shown that THC can stimulate some cancers. "THC offers some promise, but we have a long way to go before we know what its potential is," she said


By Peter Gorman
High Times, December 1994
There are now 30 diseases listed under the condition known as Acquired Immune Deficiency Syndrome, AIDS. Most AIDS sufferers will contract several of these 30 during the course of their illness before finally succumbing to one of them. The traditional medications used in both their treatment and as prophylaxis - or prevention - cause a wide range of side effects, including loss of appetite, nausea, headaches, depression, pain, disorientation and fevers. Virtually the only medicine capable of treating the entire spectrum of side effects without causing harm to the user is marijuana. Naturally, it remains illegal.

Jim Barnes was 38 years old when High Times first contacted him in the fall of 1993. The Michigan resident had tested positive for the Human Immunodeficiency Virus, HIV, in 1986. In 1987 he began a regimen that included AZT treatment, an antiretroviral therapy thought to stave off the onset of AIDS-related diseases. But the therapy's side effects included disorientation and nausea and caused pain throughout his body; he quickly switched to another antiviral therapy, an experimental drug then called ddI. According to Barnes, the ddI seemed to help for about a year, but its side effects were also difficult: he found it incredibly speedy and it caused him to fly into emotional rages. He used marijuana to calm himself, and finally quit antiviral therapy altogether in 1988.

By 1989 he became ill and was diagnosed with AIDS. "I'd come down with an intestinal disorder that caused uncontrollable diarrhea and simultaneously made me throw up everything I ate," Barnes explained. "I began to lose a lot of weight. I dropped 36 pounds, from 150 to 114, within a month."

At the time he first exhibited symptoms, Barnes was an innkeeper at a bed-and-breakfast, a program counselor at an adult foster-care home, a coordinator for a leisure activity for handicapped people and a yoga instructor. Shortly after he became ill he gave up most of his work. And most of his income.

"I couldn't afford to buy marijuana anymore, but since I knew that it helped me both with my nausea and in regulating my weight - as well as eliminating the incredible headaches I used to get from my medications - I presented my doctor with the idea of getting me federal pot." While Barnes' physician was afraid of the possible ramifications of applying to the federal government for marijuana, he did open the door to him meeting a second doctor who agreed to fill out the necessary paperwork. In 1990, Robert Randall - the Washington glaucoma sufferer who was the first person to receive medical marijuana from the federal government - helped Barnes apply to the Food and Drug Administration for the Compassionate Investigation New Drug (IND) program.

Five months later his application was approved. He was given an IND number and told that his marijuana would be arriving any day. But the marijuana never arrived. The Drug Enforcement Administration, which has to approve federal marijuana shipments, refused to recognize Barnes' case. A year later, Barnes was notified that the IND program was under review by the Bush Administration, and several months after that, the program was terminated. Barnes, one of 34 patients who were approved for the IND program but denied access to federal marijuana, continued to buy from the street when he could. But eventually his funds ran out. He starved to death on July 18, 1994 - a victim of the AIDS "wasting syndrome."
"I'm bitter about it," says Barnes' surviving partner, Gilbert Hansen, himself HIV-negative. "He was down to 87 pounds when he died. He couldn't eat. Nausea . . . well, you know that story. When he had regular marijuana, we got him up to 156 pounds at one point. But he had no marijuana available at the end. Anything we could have gotten for him we simply couldn't afford. So he, thanks to the government, actually died of starvation. If you can imagine a five-foot eight-inch skeleton, that was Jim at the end."

ma trokji curiosità:la morfina è quella che si somministra ai pazienti prima delle operazioni? si trova nell eroina?

E' questo il problema: si pretende si sentenziare su argomenti che non si conoscono per nulla, mentre basterebbe leggersi un libro

insomma, ha tanti pro (non possiamo negarli) ma anche tanti contro (stesso discorso)

la vedo più come un farmaco che come una sostanza da divertimento e quindi credo sia giusto trattarlo come tale (come fanno in alcuni paesi)
ovvero l uso deve essere prescritto da persone competenti in situazioni di necessità

Peccato che prima di questo thread tu sostenessi solo effetti negativo tout court. Più che possiamo direi posso, dato che tu li negasti, mentre io non ho mai negato nè i benefici, nè i problemi. Peccato che abbiamo già ampiamente detto come il "la vedo più come.." sia dettato dal pregiudizio, null'altro

[David23]

Trokìj la mia "curiosita" era una provocazione non hai capito va be LOL

[Trokji]

Beh non si capiva. Comunque il mio invito è comunque valido ad informarsi su un argomento da vari punti di vista, anche su quello fisiologico/biologico. Se poi uno già ne sa abbastanza meglio così

[Big Biceps]

Originariamente inviato da Trokji

Peccato che prima di questo thread tu sostenessi solo effetti negativo tout court. Più che possiamo direi posso, dato che tu li negasti, mentre io non ho mai negato nè i benefici, nè i problemi. Peccato che abbiamo già ampiamente detto come il "la vedo più come.." sia dettato dal pregiudizio, null'altro

caro mio questo NON è VERO! io ho sempre e solo parlato dei problemi che derivano dall uso di droghe! altro che storie! anzi, anzi, dato che tu mi avevi tirato fuori il discorso "terapeutico" io son stato IL PRIMO a sostenere (rileggiti i miei post addietro!) che lo scopo terapeutico è TUTTA ALTRA COSA! per favore torna indietro di una due pagine e vedrai! io critico l uso allo scopo di divertimento considerando i sides, ma non un eventuale uso terapeuticio prescritto da persone competenti!

ps: non è un muro a muro insensato del tutto, prova quello che dico, ci sono pro e contro ed è per quello che non deve essere legalizzata ma usata (come molti altri paesi) a scopo terapeutico in situazioni di necessità!

[Big Biceps]

dettato dal pregoudizio dici? e lo stabilisci tu che io ho dei pregiudizi?? ma che ne sai? io vedo studi e studi dove uno elenca i benefici e gli altri gli effetti collaterali! altro che pregiudizi! quindi la mia frase ha un senso logico, per favore non raccontiamoci balle di fronte all evidenza!

[Yashiro]

Ok basta.