info stanozololo vs methylepitiostanol

[farmacologo]

Originariamente inviato da THEHUGE

Dihydrotestosterone heptanoate: synthesis, pharmacokinetics, and effects on hypothalamic-pituitary-testicular function.

Keenan BS, Eberle AJ, Sparrow JT, Greger NG, Panko WB.
Abstract

Dihydrotestosterone heptanoate (DHT-hp), a seven-carbon fatty acid ester of DHT, was synthesized, and its pharmacokinetics and effects on hypothalamic-pituitary-testicular function were determined in men and pubertal boys. Plasma DHT levels markedly increased 24 h after im injection of DHT-hp, reached their peak during the first week, and fell to baseline levels after 4-6 weeks. An estimated 43-55% of DHT-hp was converted to DHT 4-6 weeks after injection. Plasma testosterone, estradiol, LH, and FSH levels decreased by 4 days after DHT-hp injection, were lowest during the second week, and returned to baseline values after 4-6 weeks. The LH and FSH responses to GnRH were diminished by chronic administration of DHT-hp to pubertal boys at 3-week intervals for 15 weeks. The affinity of DHT-hp was 100 times less than the affinity of DHT for the human androgen receptor, and no affinity for the estrogen receptor in breast tissue could be demonstrated. Since DHT is a nonaromatizable androgen, and neither DHT nor DHT-hp binds readily to the estrogen receptor, suppression of LH and FSH secretion by this drug probably occurs via an androgen-dependent mechanism. Receptor binding and pharmacokinetic data indicate that unesterified DHT is the active principle. DHT-hp is a useful derivative of DHT, since prompt, predictable, and sustained rises in DHT occur after its administration.

Si però bisogna considerare una cosa...così come il testosterone "pompa" i muscoli, il DHT "pompa" le palle (scusatemi per la franchezza) ed in generale il sistema riproduttivo, visto che sono li la maggior parte dei recettori per il DHT.

Quindi, a differenza di una somministrazione di testosterone che provoca atrofia testicolare e ginecomastia, una somministrazione di DHT dovrebbe provocare un effetto opposto, ovvero una ipertrofia dell'apparato riproduttivo...per questo ho detto che il DHT ha un azione opposta rispetto al testosterone difatti dallo studio che hai postato dopo si dice che è usato con succeto contro la ginecomastia...

Ero convisto che essendo la forma un composto con azione puramente androgenica non avesse potere inibitorio sull' asse, invece a quanto pare la ha anche lui...grazie per aver postato questi studi