Efficacia L-glutammina

[Trokji]

Allora ieri ho trovato questo articolo molto scettico sulla glutammina.. però pare sia una rassegna sistematica.. quindi non un semplice studio.. ma trae le fila da numerosi altri studi. Stamattina però devo dire ho trovato anche alcuni studi che mostrano una qualche utilità dell'integrazione.. per adesso però posto questo.. in genere le rassegne sistematiche hanno un loro peso, molto di più rispetto ai clinical trials ecc


J Nutr. 2008 Oct;138(10):2045S-2049S.
Dosing and efficacy of glutamine supplementation in human exercise and sport training.

Gleeson M.

School of Sport and Exercise Sciences, Loughborough University, Loughborough LE11 3TU England. m.gleeson@lboro.ac.uk

Some athletes can have high intakes of l-glutamine because of their high energy and protein intakes and also because they consume protein supplements, protein hydrolysates, and free amino acids. Prolonged exercise and periods of heavy training are associated with a decrease in the plasma glutamine concentration and this has been suggested to be a potential cause of the exercise-induced immune impairment and increased susceptibility to infection in athletes. However, several recent glutamine feeding intervention studies indicate that although the plasma glutamine concentration can be kept constant during and after prolonged strenuous exercise, the glutamine supplementation does not prevent the postexercise changes in several aspects of immune function. Although glutamine is essential for lymphocyte proliferation, the plasma glutamine concentration does not fall sufficiently low after exercise to compromise the rate of proliferation. Acute intakes of glutamine of approximately 20-30 g seem to be without ill effect in healthy adult humans and no harm was reported in 1 study in which athletes consumed 28 g glutamine every day for 14 d. Doses of up to 0.65 g/kg body mass of glutamine (in solution or as a suspension) have been reported to be tolerated by patients and did not result in abnormal plasma ammonia levels. However, the suggested reasons for taking glutamine supplements (support for immune system, increased glycogen synthesis, anticatabolic effect) have received little support from well-controlled scientific studies in healthy, well-nourished humans.

Qui il link al testo completo che è gratuito : Dosing and Efficacy of Glutamine Supplementation in Human Exercise and Sport Training -- Gleeson 138 (10): 2045S -- Journal of Nutrition