Interessante, forscolina

**Antò** · **Interessante, forscolina -** 29-11-2007, 11:37 AM

FYI- The forskolin dosages used in this study are the exact same as what is used in 6 capsules of Drive- notice the positive effects on lbm and free test

Obes Res. 2005 Aug;13(8):1335-43. Links
Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.Godard MP, Johnson BA, Richmond SR.
University of Kansas, Department of Health, Sport and Exercise Sciences, Applied Physiology Laboratory, Lawrence, KS 66045, USA. mgodard@ku.edu

OBJECTIVE: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI > or = 26 kg/m(2)) men. RESEARCH METHODS AND PROCEDURE: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks. RESULTS: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p < or = 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p < or = 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p = 0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p < or = 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group. DISCUSSION: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.

500mg di foscolina standardizzata al 10%. L'aumento del 33% di testo nn è niente male. La foscolina è un inibibitrice sistemica delle PDE, aumenta quindi il Camp in tutti i "settori" mgliorando la sensibilità recettoriale agli ormoni. A livello delle gonadi aumentare il Camp intracellulare porta ad avere un aumento della sintesi di testosterone senza alcun aumento dell'LH.
Certo, aumentare il Camp in modo sistemico nn è certo un bene, rende + "sensibili" a qualsiasi ormone inoltre potrebbe rallentare la sintesi proteica. L'aumento del Camp è legato anche all'aumento di AMPK e questo è legato ad una sottoregolazione della sintesi proteica via mTOR.
Un inibitore selettivo delle PDE5/8 (legate alle gonadi) sarebbe meglio...

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Antò Ruan Messaggi: 1,806 Data registrazione: Mar 2005 Località: catanisi sugnu Età: 42	Interessante, forscolina - 29-11-2007, 11:37 AM Interessante, forscolina FYI- The forskolin dosages used in this study are the exact same as what is used in 6 capsules of Drive- notice the positive effects on lbm and free test Obes Res. 2005 Aug;13(8):1335-43. Links Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.Godard MP, Johnson BA, Richmond SR. University of Kansas, Department of Health, Sport and Exercise Sciences, Applied Physiology Laboratory, Lawrence, KS 66045, USA. mgodard@ku.edu OBJECTIVE: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI > or = 26 kg/m(2)) men. RESEARCH METHODS AND PROCEDURE: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks. RESULTS: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p < or = 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p < or = 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p = 0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p < or = 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group. DISCUSSION: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity. 500mg di foscolina standardizzata al 10%. L'aumento del 33% di testo nn è niente male. La foscolina è un inibibitrice sistemica delle PDE, aumenta quindi il Camp in tutti i "settori" mgliorando la sensibilità recettoriale agli ormoni. A livello delle gonadi aumentare il Camp intracellulare porta ad avere un aumento della sintesi di testosterone senza alcun aumento dell'LH. Certo, aumentare il Camp in modo sistemico nn è certo un bene, rende + "sensibili" a qualsiasi ormone inoltre potrebbe rallentare la sintesi proteica. L'aumento del Camp è legato anche all'aumento di AMPK e questo è legato ad una sottoregolazione della sintesi proteica via mTOR. Un inibitore selettivo delle PDE5/8 (legate alle gonadi) sarebbe meglio...