Bene, un po' di padellate in faccia random, chi vuole se le prenda:

No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes.

Arginine supplementation has been shown to alleviate endothelial dysfunction and improve exercise performance through increasing nitric oxide production in patients with cardiopulmonary diseases. In addition, arginine supplementation could decrease accumulations of lactate and ammonia, metabolites involved in development of muscular fatigue. The aim of this study was to investigate the effect of short-term arginine supplementation on performance in intermittent anaerobic exercise and the underlying mechanism in well-trained male athletes. Ten elite male college judo athletes participated with a randomized crossover, placebo-controlled design. The subjects consumed 6 g/day arginine (ARG trial) or placebo (CON trial) for 3 days then performed an intermittent anaerobic exercise test on a cycle ergometer. Blood samples were collected before supplementation, before and during exercise and 0, 3, 6, 10, 30 and 60 min after exercise. ARG trial had significantly higher arginine concentrations than CON trial at the same time point before, during and after exercise. In both trials, nitrate and nitrite concentration was significantly higher during and 6 min after exercise comparing to the basal concentration. The increase in nitrate and nitrite concentration during exercise in both trials was parallel to the increase in plasma citrulline concentrations. There was no significant difference between the 2 trials in plasma nitrate and nitrite, lactate and ammonia concentrations and peak and average power in the exercise. The results of this study suggested that short-term arginine supplementation had no effect on nitric oxide production, lactate and ammonia metabolism and performance in intermittent anaerobic exercise in well-trained male athletes

Effects of dietary L-arginine intake on cardiorespiratory and metabolic adaptation in athletes.

To assess the effect of diet enrichment with L-arginine or supplementation at high doses on physiological adaptation during exercise, 9 athletes followed 3 different diets, each over 3 consecutive days, with a wash-out period of 4 d between training sessions: control diet (CD), 5.5 +/- 0.3 g/d of L-arginine; Diet 1 (rich in L-arginine food), 9.0 +/- 1.1 g/d of L-arginine; and Diet 2 (the same as CD but including an oral supplement of 15 g/d), 20.5 +/- 0.3 g/d of L-arginine. Plasma nitrate levels of each participant were determined on the day after each treatment. Participants performed a submaximal treadmill test (initial speed 10-11 km/hr, work increments 1 km/hr every 4 min until 85-90% VO2max, and passive recovery periods of 2 min). Oxygen uptake and heart rate were monitored throughout the test. Blood lactate concentration ([La-]b) was determined at the end of each stage. Repeated-measures ANOVA and paired Student's t tests were used to compare the various physiological parameters between diets. The level of significance was set at p < .05. [La-]b showed a significant effect at the 5-min time point between CD and Diet 2 (CD 3.0 +/- 0.5 mM, Diet 2 2.5 +/- 0.5 mM, p = .03), but this tendency was not found at higher exercise intensities. No significant differences were observed in any of the cardiorespiratory or plasma nitrate levels. In conclusion, dietary L-arginine intake on the days preceding the test does not improve physiological parameters during exercise.

Acute supplementation with the nitric oxide precursor L-arginine does not improve cardiovascular performance in patients with hypercholesterolemia.

Endothelial dysfunction based on lack of nitric oxide (NO) may contribute to several settings of cardiovascular disorder. Chronic oral supplementation with the NO precursor L-arginine counteracts the development of aortic atherosclerosis in cholesterol-fed rabbits, and i.v. infusion of L-arginine may acutely improve endothelium-dependent coronary epicardial vasodilation in patients with hypercholesterolemia (HC). To clarify whether excess NO precursor may also improve general cardiovascular performance in HC, we measured working capacity indices of myocardial ischemia, and basal and post-occlusive forearm and skin blood flow in nine patients with elevated plasma cholesterol (9.1 +/- 0.2 mumol/l) following random double-blinded administration of L-arginine (16 g i.v.) or placebo. Infusion of L-arginine raised the plasma concentration of this amino acid from 85 +/- 12 to 2460 +/- 230 mumol/l but did not change the plasma level of the major NO metabolite nitrate. Maximal working capacity, indices of myocardial ischemia, and basal and post-occlusive blood flow in the skin or forearm did not differ between the treatments. The lack of positive effect of L-arginine compared to placebo indicates that excess NO precursor did not improve microvascular endothelial function in the patients, or alternatively, that the indices measured in the present study were not dependent on endothelial microvessel function. Thus, in patients with HC, deficiency of precursor for NO formation does not seem to impair either maximal exercise capacity myocardial perfusion during maximal exercise, or maximal vasodilator capacity in skeletal muscle or skin.

L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.

BACKGROUND: L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arginine on vascular reactivity and functional capacity in patients with PAD. METHODS AND RESULTS: The Nitric Oxide in Peripheral Arterial Insufficiency (NO-PAIN) study was a randomized clinical trial of oral L-arginine (3 g/d) versus placebo for 6 months in 133 subjects with intermittent claudication due to PAD in a single-center setting. The primary end point was the change at 6 months in the absolute claudication distance as assessed by the Skinner-Gardner treadmill protocol. L-arginine supplementation significantly increased plasma L-arginine levels. However, measures of nitric oxide availability (including flow-mediated vasodilation, vascular compliance, plasma and urinary nitrogen oxides, and plasma citrulline formation) were reduced or not improved compared with placebo. Although absolute claudication distance improved in both L-arginine- and placebo-treated patients, the improvement in the L-arginine-treated group was significantly less than that in the placebo group (28.3% versus 11.5%; P=0.024). CONCLUSIONS: In patients with PAD, long-term administration of L-arginine does not increase nitric oxide synthesis or improve vascular reactivity. Furthermore, the expected placebo effect observed in studies of functional capacity was attenuated in the L-arginine-treated group. As opposed to its short-term administration, long-term administration of L-arginine is not useful in patients with intermittent claudication and PAD.

Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

Pharmacological sodium nitrate supplementation has been reported to reduce the O2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic nitrate in the form of beetroot juice (BR) would reduce the O2 cost of submaximal exercise and enhance the tolerance to high-intensity exercise. In a double-blind, placebo (PL)-controlled, crossover study, eight men (aged 19-38 yr) consumed 500 ml/day of either BR (containing 11.2 +/- 0.6 mM of nitrate) or blackcurrant cordial (as a PL, with negligible nitrate content) for 6 consecutive days and completed a series of "step" moderate-intensity and severe-intensity exercise tests on the last 3 days. On days 4-6, plasma nitrite concentration was significantly greater following dietary nitrate supplementation compared with PL (BR: 273 +/- 44 vs. PL: 140 +/- 50 nM; P < 0.05), and systolic blood pressure was significantly reduced (BR: 124 +/- 2 vs. PL: 132 +/- 5 mmHg; P < 0.01). During moderate exercise, nitrate supplementation reduced muscle fractional O2 extraction (as estimated using near-infrared spectroscopy). The gain of the increase in pulmonary O2 uptake following the onset of moderate exercise was reduced by 19% in the BR condition (BR: 8.6 +/- 0.7 vs. PL: 10.8 +/- 1.6 ml.min(-1).W(-1); P < 0.05). During severe exercise, the O2 uptake slow component was reduced (BR: 0.57 +/- 0.20 vs. PL: 0.74 +/- 0.24 l/min; P < 0.05), and the time-to-exhaustion was extended (BR: 675 +/- 203 vs. PL: 583 +/- 145 s; P < 0.05). The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for our understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans

Effects of dietary nitrate on oxygen cost during exercise.

AIM: Nitric oxide (NO), synthesized from l-arginine by NO synthases, plays a role in adaptation to physical exercise by modulating blood flow, muscular contraction and glucose uptake and in the control of cellular respiration. Recent studies show that NO can be formed in vivo also from the reduction of inorganic nitrate (NO(3) (-)) and nitrite (NO(2) (-)). The diet constitutes a major source of nitrate, and vegetables are particularly rich in this anion. The aim of this study was to investigate if dietary nitrate had any effect on metabolic and circulatory parameters during exercise. METHOD: In a randomized double-blind placebo-controlled crossover study, we tested the effect of dietary nitrate on physiological and metabolic parameters during exercise. Nine healthy young well-trained men performed submaximal and maximal work tests on a cycle ergometer after two separate 3-day periods of dietary supplementation with sodium nitrate (0.1 mmol kg(-1) day-1) or an equal amount of sodium chloride (placebo). RESULTS: The oxygen cost at submaximal exercise was reduced after nitrate supplementation compared with placebo. On an average Vo(2) decreased from 2.98 +/- 0.57 during CON to 2.82 +/- 0.58 L min(-1) during NIT (P < 0.02) over the four lowest submaximal work rates. Gross efficiency increased from 19.7 +/- 1.6 during CON to 21.1 +/- 1.3% during NIT (P < 0.01) over the four lowest work rates. There was no difference in heart rate, lactate [Hla], ventilation (VE), VE/Vo(2) or respiratory exchange ratio between nitrate and placebo during any of the submaximal work rates. CONCLUSION: We conclude that dietary nitrate supplementation, in an amount achievable through a diet rich in vegetables, results in a lower oxygen demand during submaximal work. This highly surprising effect occurred without an accompanying increase in lactate concentration, indicating that the energy production had become more efficient. The mechanism of action needs to be clarified but a likely first step is the in vivo reduction of dietary nitrate into bioactive nitrogen oxides including nitrite and NO.

Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets

The conversion of plasma citruiline to arginine approximated 5.5 ,umol*kg'l-hr-1 for the various groups and also was unaffected by arginine intake. Thus, endogenous arginine synthesis is not responsive to acute alterations in arginine intake in healthy adults. We propose that arginine homeostasis is achieved largely via modulating arginine intake and/or the net rate of arginine degradation.

Arginine is subjected to extensive degradation via arginase-1, thereby diminishing the bioavailability and terminal half-life:



Br J Clin Pharmacol. 1999 March; 47(3): 261–266.
Oranee Tangphao et al.
Pharmacokinetics of intravenous and oral l-arginine in normal volunteers

Studies in humans have also demonstrated that total body arginine homeostasis is related to the rate of degradation by hepatic arginase [22]. The activity of this enzyme is directly related to the concentration of arginine substrate

J Sports Med Phys Fitness. 2010 Mar;50(1):52-6.
Olek RA et al.
A single oral intake of arginine does not affect performance during repeated Wingate anaerobic test.

Abstract
AIM: The ergogenic effect of arginine has been demonstrated in research focusing on its intake before exercise. However, in these studies, the effect of arginine in combination with other various metabolites were assessed. The aim of this study was to determine whether a single oral intake of arginine, without any other compounds, 60 minutes prior to exercise, modifies performance and exercise metabolism during a repeated Wingate anaerobic test. METHODS: Six healthy, active, but not highly trained volunteers participated in the study. Subjects performed three 30s all-out supramaximal Wingate Anaerobic Tests (WAnTs) with 4 minute-interval rest periods between WAnTs. RESULTS: Arginine ingestion before exercise did not influence physical performance. Triple WAnTs resulted in a marked increase in white blood cell (WBC) count, lactate and ammonia concentrations, however there were no differences between arginine and the placebo trials. CONCLUSION: Our data indicated that 2 g of arginine ingested in a single dose, neither induced nitrite/nitrate (NOx) concentrations changes, nor improved physical performance

nitrates and nitrites in meat can convert to carcinogenic nitrosamines when cooked at high temperatures

Antioxidants reduce the development of nitrosamines from nitrates, chemicals that are commonly used in processed foods. Once formed, nitrosamine can become carcinogens. In several human studies(8), in which the subjects consumed a nitrosamine precursor, the urinary levels of nitrosamines were significantly reduced by vitamin C.

The carcinogenic potential of heterocyclic amines and/or N-nitrosamines, pertains to meats cooked at temperatures at and/or above 392 degrees fahrenheit

There are hundreds of thousands (or even millions) of cardiac patients who receive nitrates day in day out as a treatment for their coronary syndrome.
I am not aware of any investigation or study that would indicate reduced life-expectany, higher cancer incidence rates or any other malaise in coronary patients receiving nitrates vs. those who do not receive them. If nitrates were that dangerous, then all these patients would be exposed to a significantly higher risk for dementia, cancer, diabetes etc. However, they aren't.
That tells us alot about the potential harm from nitrates or the lack thereof.

It is however very important to note that we are speaking strictly about nitrates, and not about nitirites or even nitrosamines.

There is no evidence that nitrate or nitrite as such cause cancer in animals (ECETOC, 1988). However, a causative connection between nitrate/nitrite and cancer through the formation of N-nitroso compounds is suspected.

The role of nitrate and nitrite in the etiology of cancer in humans, especially gastric cancer, is addressed in numerous studies which are reviewed and discussed by Walker (1990), Forman et al. (1989), ECETOC (1988), IARC (1987) and WHO (1985). Included are also epidemiological studies seeking to find correlation between frequency of cancer and nitrate intake with food and water. Evidence from these sources does not support the hypothesis of a straightforward cause and effect association between nitrate exposure and cancer risk (Forman, 1989).

J Food Prot. 2002 May;65(5):872-5.
Evidence that ingested nitrate and nitrite are beneficial to health.Archer DL.

The literature was reviewed to determine whether ingested nitrate or nitrite may be detrimental or beneficial to human health. Nitrate is ingested when vegetables are consumed. Nitrite, nitrate's metabolite, has a long history of use as a food additive, particularly in cured meat products. Nitrite has been a valuable antibotulinal agent in cured meats and may offer some protection from other pathogens in these products as well. Nitrite's use in food has been clouded by suspicions that nitrite could react with amines in the gastric acid and form carcinogenic nitrosamines, leading to various cancers. Nitrate's safety has also been questioned, particularly with regard to several cancers. Recently, and for related reasons, nitrite became a suspected developmental toxicant. A substantial body of epidemiological evidence and evidence from chronic feeding studies conducted by the National Toxicology Program refute the suspicions of detrimental effects. Recent studies demonstrate that nitrite, upon its ingestion and mixture with gastric acid, is a potent bacteriostatic and/or bactericidal agent and that ingested nitrate is responsible for much of the ingested nitrite. Acidified nitrite has been shown to be bactericidal for gastrointestinal, oral, and skin pathogenic bacteria. Although these are in vitro studies, the possibility is raised that nitrite, in synergy with acid in the stomach, mouth, or skin, may be an element of innate immunity.

Since nitrates are naturally abundant in many vegetables and also present in meat, their safety is well established. In fact, in a recent study researchers provided the subject with 700mg of nitrate per day and as they said “The BR supplementation regimen implemented in this study was well tolerated with no deleterious side effects”. The beneficial effects of nitrate supplementation included lower BP, 20% less needed oxygen for muscle work and increased time to failure. (43)

Magari piu' tardi se ho tempo continuo. Nel frattempo vi comunico che la mia presenza qui era intesa a combattere la disinformazione ed aiutarvi, se devo lottare contro dogmi assurdi dal sapore quasi mistico ed inoppugnabili false verita' prive d'alcun supporto scientifico beh, magari lascio stare.
Allo stesso modo non m'imbarco in disquisizioni teologiche con un prete.

Bella carrellata Huge, interessante.
Sopratutto (parlo personalmente) le ultime parti su nitriti e nitrati che mi preoccupavano da un pò..

Dai HUGE...non farti pregare che non prego nemmeno il Signore:D. Figa, mi hai fatto perdere mezzora e due diottrie a leggere tutto, ma davvero interessante!!!:D

Grazie anche per quelli sui nitriti/nitrati:)

grazie THEHUGE

qui pero c'e' uno studio del 2010 sull'arginina e il consumo di o2

Acute L-arginine supplementation reduces the O2 co... [J Appl Physiol. 2010] - PubMed result

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance.
Bailey SJ, Winyard PG, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Jones AM.

1Exeter University.
Abstract
It has recently been reported that dietary nitrate supplementation which increases plasma nitrite concentration, a biomarker of nitric oxide (NO) availability, improves exercise efficiency and exercise tolerance in healthy humans. We hypothesised that dietary supplementation with L-arginine, the substrate for nitric oxide synthase (NOS), would elicit similar responses. In a double-blind, crossover study, nine healthy males (aged 19-38 years) consumed a 500 mL beverage containing 6 g of L-arginine (ARG) or a placebo beverage (PLA), and completed a series of 'step' moderate-intensity and severe-intensity exercise bouts 1 h post-ingestion. Plasma [nitrite] was significantly greater following L-arginine consumption compared to placebo (ARG: 331 +/- 198 vs. PLA: 159 +/- 102 nM; P<0.05) and systolic blood pressure was significantly reduced (ARG: 123 +/- 3 vs. PLA: 131 +/- 5 mmHg; P<0.01). The steady-state VO(2) during moderate-intensity exercise was reduced by 7% in the ARG condition (ARG: 1.48 +/- 0.12 vs. PLA: 1.59 +/- 0.14 L*min(-1); P<0.05). During severe-intensity exercise, the VO(2) slow component amplitude was reduced (ARG: 0.58 +/- 0.23 vs. PLA: 0.76 +/- 0.29 L*min(-1); P<0.05) and the time-to-exhaustion was extended (ARG: 707 +/- 232 s vs. PLA: 562 +/- 145 s; P<0.05) following ARG. In conclusion, similar to the effects of increased dietary nitrate intake, elevating NO bioavailability through dietary L-arginine supplementation reduced the O(2) cost of moderate-intensity exercise and blunted the VO(2) slow component and extended the time-to-exhaustion during severe-intensity exercise.

anche io come gli altri voglio ringraziarti, te lo avevo gia detto che per me qui la tua presenza è una cosa molto importante.

io ho solo insistito a chiedere perche volevo capire meglio questa cosa solo per "sete" di conoscenza e curiosità.
per me è importante sapere e conoscere le cose quando posso.

a me non costa nulla togliere l''arginina dalla mia integrazione.

pero mi chiedo se non dovesse funzionare come mai con me e altre persone ha funzionato ??
parlo di effetto pump, vascolarizzazione ecc ...

insomma thehuge io vermanete ti ringrazio per la tua presenza e la tua disponibilità qui e lo sai

concludendo non reputo l'arginina un integratore inutile perchè ha dimostrato avere molte funzioni

mi autoquoto solo per dire che qui nessuno ha detto questo, solo che leggendo queste ultime pagine qualcuno poteva saltare a queste conclusioni
a me fa strano anche perchè gli studi della produzione del no da parte dell'arginina erano stati condotti da piu medici non solo per l'ambito sportivo
quindi in poche parole per la produzione del no non servirebbero piu citrullina e arginina ma basterebbe la presenza di nitrati nei blend ??

si credo che bastano alcuni mg di nitrati

domanda...

l'arginina nitrato funziona???

per promuovere l'effeto pump e del no basta che ci siano i nitrati
ad esempio nel power shock ci sono bcaa nitrati, citrullina nitrata e beta alanina nitrata

volevo sapere emivita dei nitrati e se c'era qualche tolleranza che poteva sviluppare il corpo ad essi

Dovrebbe anche essere notificato Great, o sbaglio?

si l'ho visto su un negozio italiano

Niente(o quasi) e' "inutile" nel senso stretto del termine, ma "efficace" ha un'altra accezione nel mio vocabolario. Inoltre, anche se avesse una qualche efficacia, mi domando perche' optare per la scelta peggiore quando si hanno delle alternative.
Ti pongo una domanda: sei solito assumere solo arginina pre-wo? In caso negativo, come puoi discernere tra i suoi effetti e quelli degli altri ingredienti? Sai che bere un gatorade prima d'allenarti aumenta la percezione di "pompaggio" notevolmente senza nessun effetto sull'ossido nitrico, ad esempio?

Si', come qualunque aminoacido nitrato.

Parliamo di rilevanza statistica: se uno studio suggerisce un trend ed altri 20 quello opposto quali deduzioni e' logico trarre?

Ecco comunque un altro motivo per riconsiderare l'uso dell'arginina pre-wo:
Oral arginine attenuates the growth hormone response to resistance exercise -- Collier et al. 101 (3): 848 -- Journal of Applied Physiology

si ma come è possibile che in certi studi funziona e in altri no ?

sul discorso che i nitrati funzionino meglio sono d'accordo, pero l'arginina almeno da certi studi che ho visto ha pure altre funzioni
quindi se uno ricerca il pump è giusto "buttarsi" sui nitrati

solo arginina non l'ho mai assunta quindi non posso dirti, pero ci sono stati prodotti che a parita di dosaggi funzionavano meglio quindi dipende dai blend e dalle sostanze che sono all'interno sicuro.

la citrullina da sola invece la provai e su quella posso dare la mia personale esperienza dicendo che funzionava meglio e prima rispetto a tanti altri prodotti

su di me anche il nitrix ha funzionato molto bene a disaggi alti.

forse bisognerebbe fare studi migliori magari usando un mix di sostanze per migliorare la qualità dell'arginina, capire qual'è la forma migliore.
molti blend hanno all'interno la norvalina, valina e altre cose per contrastare l'arginasi

il mio è un discorso generale, certo nel tuo caso è giusto invece trovare le cose migliori come hai sempre fatto.

ti rifaccio la domanda dato che mi interessa:
quant'è l'emivita dei nitrati dato che molti prodotti li si assume solo nei giorni di allenamento.
e poi il corpo sviluppa una tolleranza ad essi ?

grazie :)

anche a me il nitrix della bsn funziona bene , io lo sento molto quando lo uso ....

Following completion of the ramp test, subjects were randomly assigned, using a double-blind cross-over design, to receive three consecutive days of dietary supplementation with a commercially available L-arginine product (ARG; Arkworld ARK 1, Arkworld International, Inc, USA, administered in 0.5 L water), or placebo (PLA; 0.5 L blackcurrant flavor cordial). Participants received a 20 g dose of the ARK 1 supplement which contained 6 g L-arginine along with trace amounts of vitamins (E, C, B6 and B12), other amino acids (L-glutamine, L-leucine, L-valine, L-carnitine, L-citrulline, L-cysteine and L-isoleucine), and fructose



Eccoti servito. Un altro studio pagliacciata. Studiamo gli effetti dell'arginina(pero' magari non diciamolo ad alta voce che c'e' anche la citrullina altrimenti si capisce che e' una bufala architettata per vendere l'arginina).

Senza offesa ma prima di spararle grosse bisogna sapere di cosa si sta parlando, altrimenti affermazioni ad effetto terroristico come questa rimangono balle.

La formazione di nitrosamine a partire dai nitrati dipende dal metabolismo della flora batterica orale. Questo ha una qualche rilevanza nel caso dei cibi interi masticati che sostano nel cavo orale relativamente a lungo. Se uno ingerisce capsule o polveri contenenti nitrati la quantita' di nitriti che raggiungono lo stomaco e' praticamente zero. Allo stesso modo lo stomaco umano e' un ambiente molto povero per la conversione nitrati-->nitriti e l'intestino tenue e' asettico(zero conversione) quindi lo spauracchio della conversione nitrati-->nitrosamine con creatina e/o aminoacidi nitrati e' fondamentalmente una idiozia.

potresti illustrare meglio il meccanismo di conversione da nitrati in nitrosammine cosi da capire perchè avviene solo ad opera della flora batterica orale?
thx:p

anche io volevo capire meglio questo processo, se c'era qualche interazione con la creatina come si è visto in vivo, o con le proteine e i cibi.
se ci sono delle linee guida da seguire quando si consumano questi tipi di integratori
quindi nell'ambiente gastrico nello stomaco non avviene nessun processo di trasformazione?
per sicurezza cmq ci dovrebbero essere sempre antiossidanti all'interno di questi prodotti

ma lo studio che mi hai postato te è lo stesso che avevo messo io ?
nel cocktail che fai vedere pero la presenza della citrullina credo sia molto bassa pero'.
strano poi non siano stati precisi nel descrivere il cocktail mettendo le quantità di ogni singolo ingrediente
a volte penso che molti studi siano fatti male e non verificati sufficientemente, e quando positivi le case li utilizzino subito per realizzare i loro prodotti.

ho visto un negozio on line italiano con sede in italia la vendita del power shock della vpx quindi è da considerare sicuro l'utilizzo dei nitrati in italia ?


l'effetto pump di prodotti come il nitrix quindi principalmente a base di arginina come mai hanno funzionato?
insomma prima dell'utilizzo dei nitrati in ambito sportivo mi sembra che gia esistevano prodotti che davano a molti l'effetto pump
anche se si vanno a leggere i feedback di chi ha utilizzato la sola aakg o sola arginina in varie forme ha riscontrato buoni effetti di pump

l'emivita dei nitrati dovrebbe essere dall 10-16 ore giusto ??
poi il corpo sviluppa una certa tolleranza ad essi e l'arginina aiuta ad ovviare a questa cosa
quindi mettere dell'arginina all'interno potrebbe essere una buona soluzione

il Power shock della Vpx stando alla composizione ed a quello che si è detto qui, sembra il più mirato alla stimolazione e produzione di NO.
Personalmente non conosco la Vpx come casa...è seria ?

Meglio ancora sarebbe la norvalina per prevenire un calo dell'argininemia dovuta ai nitrati.

No. Inoltre i prop. blend non fanno per me.

Allora su quale prodotto orientarsi ?

Il POW avrà amino nitrati ?

Se riesci a trovarlo in EU o UK ci sarebbe l'Ice Plus dell'Xtreme formulation, questa la composizione:

375 Capsules
Supplement Facts
Serving Size15Capsules
Servings Per Container25

Amount Per Serving % DV

BCAA Nitrate Complex
L-Leucine: 3500mg *
Leucine Nitrate: 500mg *
L-Isoleucine: 1800mg *
Isoleucine Nitrate: 250mg *
L-Valine: 1800mg *
Valine Nitrate: 250mg *

Beta Alanine: 1000mg *
Citrulline Malate: 1000mg *
L-Norvaline: 100mg *

Vitamin B6: 10mg 1250%
(As Pyridoxine HCL)
Vitamin B12: 500mcg 8333%
(As Methylcobalamin)

* Daily Value not established

Other Ingredients:
Gelatin (Capsule), Potassium Bicarbonate, Microcrystalline Cellulose

Altrimenti ci sarebbero il SAN Launch o il CM2 Nitrate che contengono Creatina Nitrato. A breve proverò il primo.
Negli USA è poi appena uscito il Pump Bol. A quanto ricordo i prodotti Thermolife non impiegano molto ad arrivare in UK;)