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Predefinito Dianabol (methandrostenolone) - 26-06-2007, 05:07 AM

Dianabol (methandrostenolone)


Active Life: 6-8 hours
Drug Class: Anabolic/Androgenic Steroid (Oral)
Average Dose: Men 15-50 mg/day......Women 5-10 mg/day
Acne: Yes, especially in higher dosages
Water Retention: Yes, similar to testosterone
High Blood Pressure: Yes
Liver Toxic: Yes
Aromatization: Yes
DHT Conversion: No
Decrease HPTA function: Yes, dose and cycle length dependant
Dianabol is the old Ciba brand name for the oral steroid methandrostenolone. It is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favored and widely used anabolic steroid in all forms of athletics. This is likely due to the fact that it is both easy to use and extremely effective. In the U.S. Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80's when the last of the U.S. generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the U.S. market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the U.S. As long as there are countries manufacturing this steroid, it will probably remain so.
Similar to testosterone and anadrol 50, Dianabol is a potent steroid, but also one which brings about noticeable side effects. For starters methandrostenolone is quite estrogenic. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a pronounced problem, causing a notable loss of muscle definition as both subcutaneous water and fat build. Sensitive individuals may therefore want to keep the estrogen under control with the addition of an anti-estrogen such as nolvadex and/or Proviron. The stronger drugs Arimidex, Femara, or Aromasin (antiaromatase) would be a better choice if available.
In addition, androgenic side effects are common with this substance, and may include bouts of oily skin, acne and body/facial hair growth. Aggression may also be increased with a potent steroid such as this, so it would be wise not to let your disposition change for the worse during a cycle. With Dianabol there is also the possibility of aggravating a male pattern baldness condition. Sensitive individuals may therefore wish to avoid this drug and opt for a milder anabolic such as Deca-Durabolin. While Dianabol does convert to a more potent steroid via interaction with the 5-alpha reductase anzyme (the same enzyme responsible for converting testosterone to dihydrotestosterone), it has extremely little affinity to do so in the human body's. The androgenic metabolite 5alpha dihydromethandrostenolone is therefore produced only in trace amounts at best. Therefore the use of Proscar/Propecia would serve no real purpose.
Being moderately androgenic, Dianabol is really only a popular steroid with men. When used by women, strong virilization symptoms are of course a possible result. Some do however experiment with it, and find low doses (5mg) of this steroid extremely powerful for new muscle growth. Whenever taken, Dianabol will produce exceptional mass and strength gains. It's effectiveness is often compared to other strong steroids like testosterone and Anadrol 50, and it is likewise a popular choice for bulking purposes. A daily dosage of 20-40mg is enough to give almost anybody dramatic results. Some do venture much higher in dosage, but this practice usually leads to a more profound incidence of side effects. It additionally combines well with a number of other steroids. It is noted to mix particularly well with the mild anabolic Deca-Durabolin. Together one can expect an exceptional muscle and strength gains, with side effects not much worse than one would expect from Dianabol alone. For all out mass, a long acting testosterone ester like enanthate can be used. With the similarly high estrogenic/androgenic properties of this androgen, side effects may be extreme with such a combination however. Gains would be great as well, which usually makes such an endeavor worthwhile to the user. As discussed earlier, ancillary drugs can be added to reduce the side effects associated with this kind of cycle.
In order to withstand oral administration, this compound is c17 alpha alkylated. We know that this alteration protects the drug from being deactivation by the liver (allowing nearly all of the drug entry into the bloodstream), however it can also be toxic to this organ. Prolonged exposure to c17 alpha alkylated substances can result in actual damage, possibly even the development of certain kinds of cancer. To be safe one might want to visit the doctor a couple of times during each cycle to keep an eye on their liver enzyme values. Cycles should also be kept short, usually less than 8 weeks long to avoid doing any noticeable damage. Jaundice (bile duct obstruction) is usually the first visible sign of liver trouble, and should be looked out for. This condition produces an unusual yellowing of the skin, as the body has trouble processing bilirubin. In addition to the skin, the whites of the eyes may also yellow, a clear indicator of trouble. Should this occur the drug should be discontinued immediately and a doctor visited. This is usually a point where further, permanent damage can be avoided.
It is also interesting to note that methandrostenolone is structurally identical to boldenone (EQ), except that it contains the added c17 alpha alkyl group discussed above. This fact makes clear the impact of altering a steroid in such a way, as these two compounds appear to act very differently in the body. The main dissimilarity seems to lie in the tendency for estrogenic side effects, which seems to be much more pronounced with Dianabol. Equipoise is known to be quite mild in this way, and users therefore commonly take this drug without any need of an anti-estrogen. Dianabol is much more estrogenic not because it is more easily aromatized, as in fact the 17 alpha methyl group and c1-2 double bond both slow the process of aromatization. The problem is that methandrostenolone converts to l7alpha methylestradiol, a more biologically active form of estrogen than regular estradiol. But Dianabol also appears to be much more potent in terms of muscle mass compared to boldenone, supporting the notion that estrogen does play an important role in anabolism. In fact boldenone and methandrostenolone differ so much in their potencies as anabolics that the two are rarely though of as related. As a result, the use of Dianabol is typically restricted to bulking phases of training while Equipoise is considered an excellent cutting or lean-mass building steroid.
The half-life of Dianabol is only about 3 to 4 hours, a relatively short time. This means that a single daily dosage schedule will produce a varying blood level, with ups and downs throughout the day. The user likewise has a choice, to either split up the tablets during the day or to take them all at one time. The usual recommendation has been to divide them and try to regulate the concentration in your blood. This however, will produce a lower peak blood level than if the tablets were taken all at once, so there may be a trade off with this option. The steroid researcher Bill Roberts also points out that a single-episode dosing schedule should have a less dramatic impact on the hypothalamic-pituitary-testicular axis, as there is a sufficient period each day where steroid hormone levels are not extremely exaggerated. I tend to doubt hormonal stability can be maintained during such a cycle however, but do notice that anecdotal evidence often still supports single daily doses to be better for overall results. Perhaps this is the better option. Since we know the blood concentration will peak about 1.5 to 3 hours after administration, we may further wonder the best time to take our tablets. It seems logical that taking the pills earlier in the day, preferably some time before training, would be optimal. This would allow a considerable number of daytime hours for an androgen rich metabolism to heighten the uptake of nutrients, especially the critical hours following training.


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Predefinito 26-06-2007, 12:45 PM


Dianabol

Dbol - Methandrostenolone

This was more or less the second Anabolic Steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900´s and experimented with by Nazi´s in WW2, in an attempt to produce a better soldier.
Russian Dianabol and Team Sports History

Russian athletes in the 1953 World Championships as well as the Olympic games then used testosterone with great success. After that, John Zeigler, who was a doctor working with the US Weightlifting Team, began a cooperative project with Ciba to develop an equalizer for US atheletes. Flash forward to 1956 and enter Dianabol ; the original trade name for Ciba´s Methandrostenolone... but called "Dbol" by athletes. The original package insert said that 10mgs/day was enough to provide full androgen replacement for a man and Dr.Zeigler recommended that athletes take 5-10mgs/day. Incidentally, this is also the dose that Bodybuilders were reputed to take from then until roughly the 1970´s. Yeah, this was allegedly Arnold´s dose, Zane´s dose, etc... simply stacked with some testosterone. (For any trivia buffs out there, Dan Duchaine´s mail order steroid business operated under the name "The John Zeigler Fan Club").
Dianabol Steroid Use

Enough with the history lesson, lets get into what this stuff is, and what it does. Well, first off, it´s usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). It is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive its´ first pass through your liver, and make it into your blood stream. It´ll raise your blood pressure (4) and is also hepatoxic (Liver-Toxic), so be careful with it. Although I have known people to take up to 100mgs/day of this stuff and not suffer any ill-effects, and one study looked at that exact dose, and the people involved didn´t suffer any intolerable side effects ( 7). Lets examine this particular study a bit further, though:
In this study, done in the early 80´s, a very high dose of Dbol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of it´s normal value, plasma GH went up about a third, LH dropped to about 80% of it´s original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Body fat did not go up significantly and Fat Free Mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that Dbol increases Fat Free Mass as well as increasing strength and performance. I can only agree, having found this to be the case for me when I did my first cycle (which was 6 weeks of dbol alone at 25mgs/day), I gained roughly 25lbs and kept nearly ½ of it. Since then, Dbol has always had a special place in my heart.
Dianabol Side Effects

As with many other 17aa steroids, Dianabol is also a very weak binder to the Androgen Receptor, so most of it´s effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as indicated by the production of muscle tissue with very high levels of nitrogen, etc... which was indicated in the 100mg/day study). This also means it only has a modest aromatase activity (2).
How strong is Dbol? Well...on a mg for mg basis, most people agree that it´s stronger than A50...but the reason most people don´t get the same gains off of Dbol is that almost nobody takes equivalent doses (I mean...I´ve heard of people taking 150mgs of A50, but not Dbol, even though the dbol would probably provide more solid gains and be less toxic, I suspect).
So how do we incorporate this stuff into our AAS regimen? Clearly, the inclusion of Dbol at any point in a cycle would contribute to gains, however, I´d speculate that Dbol is most regularly used for 2 reasons:
  1. At the start of a cycle to "Kick Start" gains
  2. As a "Bridge" between cycles, to maintain gains
Lets examine these two uses.

Dbol Facts
[17a-methyl-17b-hydroxy-1,4-androstadien-3-one]
Molecular Weight: 300.44
Formula: C20H28O2
Melting Point: N/A
Manufacturer: Ciba (originally)
Release Date: 1956
Effective dose: 25-50mgs (as low as 10 and as high as 100 have been reported)
Active Life: 6-8hours
Detection Time: up to 6 weeks
Anabolic/Androgenic Ratio (Range): 90-210:40-60
References:
  1. Serakovskii S, Mats´koviak I., Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells, Farmakol Toksikol 1981 Mar-Apr;44(2):213-7
  2. Brain Res. 1998 May 11;792(2):271-6.
  3. Chemfinder. Copyright 2004 CambridgeSoft Corporation. Cambridge, MA, USA.
  4. Br Med J. 1975 May 31;2(5969):471-3.
  5. Anabolic Steroids - Steroid .com
  6. http://www.*****************.com
  7. Clin Sci (Lond). 1981 Apr;60(4):457-61
  8. Steroids. 1984 Dec;44(6):485-95.
  9. Vrach Delo. 1983 Nov;(11):34-6. Russian
  10. Acta Med Acad Sci Hung. 1975;32(1):27-34
  11. 4 Nesterin MF, Budik VM, Narodetskaia RV, Solov´eva GI, Stoianova VG., Effect of methandrostenolone on liver morphology and enzymatic activity, Farmakol Toksikol 1980 Sep-Oct;43(5):597-601

Ultima Modifica di Antò : 05-12-2007 08:59 PM.
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Antò Antò Non in Linea
Ruan
 
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Predefinito 21-11-2007, 09:52 AM


Dianabol

(Methandrostenolone)
[17a-methyl-17b-hydroxy-1,4-androstadien-3-one]
Molecular Weight: 300.44
Formula: C20H28O2
Melting Point: N/A
Manufacturer: Ciba (originally)
Release Date: 1956
Effective dose: 25-50mgs (as low as 10 and as high as 100 have been reported)
Active Life: 6-8hours
Detection Time: up to 6 weeks
Anabolic/Androgenic Ratio (Range): 90-210:40-60
Dianabol (Methandrostenolone)

This was more or less the second Anabolic Steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900’s and experimented with by Nazi’s in WW2, in an attempt to produce a better soldier. Russian athletes in the 1953 World Championships as well as the Olympic games then used testosterone with great success. After that, John Zeigler, who was a doctor working with the US Weightlifting Team, began a cooperative project with Ciba to develop an equalizer for US atheletes. Flash forward to 1956 and enter Dianabol ; the original trade name for Ciba’s Methandrostenolone... but called “Dbol” by athletes. The original package insert said that 10mgs/day was enough to provide full androgen replacement for a man…and Dr.Zeigler recommended that athletes take 5-10mgs/day. Incidentally, this is also the dose that Bodybuilders were reputed to take from then until roughly the 1970’s. Yeah…this was allegedly Arnold’s dose, Zane’s dose, etc…simply stacked with some testosterone. (For any trivia buffs out there, Dan Duchaine’s mail order steroid business operated under the name “The John Zeigler Fan Club”).

Enough with the history lesson….lets get into what this stuff is, and what it does. Well, first off, it’s usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). It is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive its’ first pass through your liver, and make it into your blood stream. It’ll raise your blood pressure (4)and is also hepatoxic (Liver-Toxic)…so be careful with it. Although I have known people to take up to 100mgs/day of this stuff and not suffer any ill-effects, and one study looked at that exact dose, and the people involved didn’t suffer any intolerable side effects ( 7). Lets examine this particular study a bit further, though:

In this study, done in the early 80’s, a very high dose of Dbol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of it’s normal value, plasma GH went up about a third, LH dropped to about 80% of it’s original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Bodyfat did not go up significantly and Fat Free Mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that Dbol increases Fat Free Mass as well as increasing strength and performance. I can only agree, having found this to be the case for me when I did my first cycle (which was 6 weeks of dbol alone at 25mgs/day)…I gained roughly 25lbs and kept nearly ½ of it. Since then, Dbol has always had a special place in my heart…

As with many other 17aa steroids, Dbol is also a very weak binder to the Androgen Receptor, so most of it’s effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as inticated by the production of muscle tissue with very high levels of nitrogen, etc… which was indicated in the 100mg/day study). This also means it only has a modest aromatase activity (2).

How strong is Dbol? Well...on a mg for mg basis, most people agree that it's stronger than A50...but the reason most people don't get the same gains off of Dbol is that almost nobody takes equivalent doses (I mean...I've heard of people taking 150mgs of A50, but not Dbol, even though the dbol would probably provide more solid gains and be less toxic, I suspect).

So how do we incorporate this stuff into our AAS regimen? Clearly, the inclusion of Dbol at any point in a cycle would contribute to gains , however, I’d speculate that Dbol is most regularly used for 2 reasons:

1. At the start of a cycle to “Kick Start” gains
2. As a “Bridge” between cycles, to maintain gains

Lets examine these two uses.

In order to kick start a cycle, usually what you do is incorporate a fast acting oral like dianabol (or anadrol) and combine it with long acting injectables (such as Deca or Eq with some Testosterone). The reasoning here is that the oral (Dbol in this case) will give almost immediate results, while the injectable takes time to produce results. The end result is that you start seeing results within the first week of your cycle and continue up until the end with the injectables. This entails taking anywhere from 25-50mgs of dbol (although as little as 20mgs or as much as 100mgs have been reported) for 3-6 weeks at the start of a cycle (average time for a “Kick Start” is 4 weeks, though), and then ceasing their use as the injectables start to produce results.

In order to successfully bridge between cycles (and this means using a low dose of AAS…in this case dbol), you need to recover your natural hormonal levels to pre-cycle levels or to within acceptable parameters, and then you start your next cycle. The idea here is that you won’t lose any gains, but rather a low dose of an AAS will help you maintain them. Typically, you’d use around 10mgs/day of dbol and combine it with an aggressive Post-Cycle Therapy (PCT) course of Nolvadex (and/or Clomid) and HCG. This would give you full androgen replacement from the Dbol and a shot at recovering your natural hormonal levels via the other stuff you are taking. Remember, the 100mg/day dose of dbol in the study we looked at earlier did not suppress Test, LH, or FSH to a degree that would make recovery impossible…and certainly not with 1/10th that dose in conjunction with an aggressive PCT.

All in all, this is a very good drug, and a potent tool for quick gains or retaining gains...when used properly and safely.

References:
1 Serakovskii S, Mats'koviak I., Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells,
[font=Times New Roman]Farmakol Toksikol 1981 Mar-Apr;44(2):213-7
2.Brain Res. 1998 May 11;792(2):271-6.
3.Chemfinder. Copyright 2004 CambridgeSoft Corporation. Cambridge, MA, USA.
4. Br Med J. 1975 May 31;2(5969):471-3.
5. Anabolic Steroids - Steroid .com
6. http://www.*****************.com
7. Clin Sci (Lond). 1981 Apr;60(4):457-61
8. Steroids. 1984 Dec;44(6):485-95.
9. Vrach Delo. 1983 Nov;(11):34-6. Russian
10. Acta Med Acad Sci Hung. 1975;32(1):27-34
11. 4 Nesterin MF, Budik VM, Narodetskaia RV, Solov'eva GI, Stoianova VG., Effect of methandrostenolone on liver morphology and enzymatic activity, Farmakol Toksikol 1980 Sep-Oct;43(5):597-601
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