Acido Ursolico

**Guru** · 11-06-2011, 12:58 PM

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.

Sembra molto promettente.

Stando a quanto scrivono, non solo aumenta la muscolatura attraverso l'aumentata risposta di questa ad IGF-1 ed insulina (il che, aggiungo io, potrebbe fargli avere anche un ruolo nel trattamento del diabete o almeno della sindrome x), ma riduce anche il grasso corporeo.

Di integratori ce ne sono ma non ne ho visti in Italia.
Diciamo anche che, fin'ora, era proposto come antiossidante/antitumorale, visto che ci sono studi a riguardo.

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Guru *Uncensored Magister* Messaggi: 25,331 Data registrazione: Jan 2005 Località: Kalepolis Età: 48	11-06-2011, 12:58 PM mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass. Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM. Source Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA. Abstract Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases. Sembra molto promettente. Stando a quanto scrivono, non solo aumenta la muscolatura attraverso l'aumentata risposta di questa ad IGF-1 ed insulina (il che, aggiungo io, potrebbe fargli avere anche un ruolo nel trattamento del diabete o almeno della sindrome x), ma riduce anche il grasso corporeo. Di integratori ce ne sono ma non ne ho visti in Italia. Diciamo anche che, fin'ora, era proposto come antiossidante/antitumorale, visto che ci sono studi a riguardo.