Acido Ursolico

[Guru]

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.

Sembra molto promettente.

Stando a quanto scrivono, non solo aumenta la muscolatura attraverso l'aumentata risposta di questa ad IGF-1 ed insulina (il che, aggiungo io, potrebbe fargli avere anche un ruolo nel trattamento del diabete o almeno della sindrome x), ma riduce anche il grasso corporeo.

Di integratori ce ne sono ma non ne ho visti in Italia.
Diciamo anche che, fin'ora, era proposto come antiossidante/antitumorale, visto che ci sono studi a riguardo.

[novellino]

Grazie per le informazioni
Quindi in effetti potrebbe essere un ottimo prodotto , ho visto che un'azienda che tratta sostanze chimiche lo ha in listino ( ma forse soltanto per uso cosmetico) , sarebbe interessante provarlo .

[orange]

Ma un quantitativo utile sarebbe irraggiungibile mangiano le mele con la buccia?

[LiborioAsahi]

Originariamente inviato da novellino

Grazie per le informazioni
Quindi in effetti potrebbe essere un ottimo prodotto , ho visto che un'azienda che tratta sostanze chimiche lo ha in listino ( ma forse soltanto per uso cosmetico) , sarebbe interessante provarlo .

Parli di quell'azienda che, subito sotto all'ursolico ha il temibile Ac Usnico?!

[novellino]

Originariamente inviato da LiborioAsahi

Parli di quell'azienda che, subito sotto all'ursolico ha il temibile Ac Usnico?!

Se l'acido usnico è titolato al 5% si , parliamo della stessa azienda

[Bomb Jack]

Originariamente inviato da Guru

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.

Sembra molto promettente.

Stando a quanto scrivono, non solo aumenta la muscolatura attraverso l'aumentata risposta di questa ad IGF-1 ed insulina (il che, aggiungo io, potrebbe fargli avere anche un ruolo nel trattamento del diabete o almeno della sindrome x), ma riduce anche il grasso corporeo.

Di integratori ce ne sono ma non ne ho visti in Italia.
Diciamo anche che, fin'ora, era proposto come antiossidante/antitumorale, visto che ci sono studi a riguardo.

...OH-MY-GOD!!!

(per me, poi, che sono uno che implementa il digiuno nel suo sistema, sarebbe perfetto...!)

...Notizie sulle dosi??

[rockclimber]

Originariamente inviato da Guru

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.

Sembra molto promettente.

Stando a quanto scrivono, non solo aumenta la muscolatura attraverso l'aumentata risposta di questa ad IGF-1 ed insulina (il che, aggiungo io, potrebbe fargli avere anche un ruolo nel trattamento del diabete o almeno della sindrome x), ma riduce anche il grasso corporeo.

Di integratori ce ne sono ma non ne ho visti in Italia.
Diciamo anche che, fin'ora, era proposto come antiossidante/antitumorale, visto che ci sono studi a riguardo.

giusto per completezza l'articoloc compare cu cell metabolism..impact factor 17.95...sti cazzi.